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wilson's disease


Kayser-Fleischer Ring

Kayser-Fleischer RingsKayser-Fleischer RingsKayser-Fleischer Rings

Definition: Kayser-Fleischer Ring:  Clinical sign. Brownish-yellow ring visible around the corneo-scleral junction (limbus).  Consists of copper deposits in Descemet’s membrane, extending into the trabecular meshwork.  Sign of Wilson’s disease.  (Dictionary of Eye Terminology, 3rd edition; Barbara Cassin, Sheila A.B. Solomon)

Description and Location: Golden to greenish-brown annular deposition of copper located in the periphery (limbus) of the cornea (Descemet’s membrane).  First appears as a superior crescent, then develops inferiorly and ultimately becomes circumferential.  Usually requires a slit-lamp examination to detect rings in their early stage of formation.

Prevalence: Approximately 95% of WD patients presenting with neurological signs will have a K-F ring.  Where as approximately 65% of WD patients presenting with hepatic signs will present with a ring.

Copper chelation therapy may cause fading and even disappearance of the corneal copper over time.



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